Healthy Aging Supplement Study (DSM)

A Study to Evaluate a Supplement's Effects on Energy and Metabolism in Healthy Adults Ages 40-70

This study involves a total of 5 in-clinic visits (located in Guelph, ON) over approximately 8 weeks. Participants who complete the study in its entirety will receive up to $1,600 in compensation for their time, travel, and participation. Total compensation will be pro-rated based on the visits you complete. Participation is voluntary.

The primary purpose of this study is to assess the effect of TP daily supplementation on NAD metabolism, as measured by NAD⁺ concentrations in blood compared to placebo. The secondary purpose of this study is to determine the bioavailability and pharmacokinetics (PK) of single dose TP among different doses of TP and compared to a comparator and placebo.

You may be eligible if you:

Are between 40 and 70 years old

Have a BMI between 18.5 and 29.9 kg/m² (inclusive) and weigh at least 110.2 lbs/50 kg

Are in good general health

Are willing to maintain a consistent activity level and avoid strenuous exercise for 48 hours before designated visits

Are comfortable with multiple blood, urine, and fecal sample collections

Are comfortable taking the study product (trigonelline, nicotinamide mononucleotide (NMN), or placebo) as 3 capsules once daily, around the same time each day, with water, for approximately 4 weeks

Do not have any sensitivity, intolerance, or allergy to wheat, fish, eggs, sesame seeds, nuts, milk, or mustard

Are available for 5 in-clinic visits (located in Guelph, ON) over approximately 8 weeks

Are willing to abstain from recreational drugs: 28 days before visit 2 until the final study procedure

Are willing to abstain from tobacco and nicotine products (including cigarettes, patches, gum and vapes): 3 months before visit 2 until the final study procedure

Are willing to abstain from alcohol and alcohol-containing products: 48 hours before visits 2, 3, 4 and 5 until the final blood draw at each visit

Are willing to abstain from coffee: For the required periods before and during applicable study visits

Only a limited amount of spots available.

Ready to participate?

SEE IF YOU QUALIFY

Healthy Aging Supplement Study

Participation will include:

5 in-clinic visits (located in Guelph, ON) over approximately 8 weeks
Oral administration of three study product capsules once daily for approximately 4 weeks
Regular health assessments and safety laboratory testing
Fasting for at least 8 hours before 4 of the 5 in-clinic visits
Multiple blood draws at all 5 in-clinic visits
Multiple urine sample collections at 2 of the 5 in-clinic visits and on 2 at-home occasions
Multiple fecal samples on 2 at-home occasions
Consumption of standardized meals and snacks during applicable study visits

How It Works:

Facility Features

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